Genomic Health
MTHFR & Genomics
Your genes load the gun — but your lifestyle pulls the trigger. Understanding your unique genetic blueprint allows us to tailor your health support from the ground up
What is MTHFR?
The Gene Behind Methylation
MTHFR (methylenetetrahydrofolate reductase) is an enzyme encoded by the MTHFR gene. It plays a critical role in processing folate and is essential for the methylation cycle — one of the most fundamental biochemical processes in your body.
Methylation occurs billions of times per second and influences DNA repair, detoxification, neurotransmitter production, immune regulation, and much more. When the MTHFR gene has a variant (often called a "mutation" or SNP), this enzyme may not work as efficiently, potentially impacting many areas of your health.
~40%of the population carry at least one MTHFR gene variant
2 main variants identified: C677T and A1298C, each with different effects on enzyme activity
Up to 70%reduction in enzyme efficiency in homozygous C677T carriers
What Methylation Affects
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🧠Mood & Mental Health
Methylation is essential for producing serotonin, dopamine, and norepinephrine. Variants may contribute to anxiety, depression, and mood instability.
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🔋 Energy & Fatigue
Proper methylation supports mitochondrial function and energy production. Variants may underlie persistent fatigue and poor recovery.
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🫀Cardio-vascular Health
Impaired methylation can elevate homocysteine — a risk factor for heart disease, stroke, and blood clotting disorders.
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🤱 Fertility & Pregnancy
Folate metabolism is critical for foetal neural development. MTHFR variants have been linked to recurrent miscarriage and neural tube issues.
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🛡️ Immune Function
Methylation regulates gene expression related to immune response, inflammation, and autoimmune risk.
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🧬 Detoxification
The methylation cycle is central to liver detox pathways. Impaired function may increase sensitivity to chemicals, medications, and environmental toxins.
Signs & Symptoms
Could MTHFR Be a Factor for You?
Having an MTHFR variant doesn't guarantee you'll have symptoms — lifestyle, nutrition, and other genes all play a role. However, the following may be more common in those with impaired methylation:
Anxiety, depression or mood disorders
Fatigue and low energy
Brain fog or poor concentration
Recurrent miscarriage
Elevated homocysteine levels
Migraines or headaches
Poor detoxification / chemical sensitivities
Autoimmune conditions
History of blood clots or cardiovascular issues
Slow recovery from illness
Poor response to standard B-vitamin supplements
Family history of MTHFR variants
A Personalised, Gene-Informed Approach
We use clinically validated testing panels that assess MTHFR, COMT, MAO-A, VDR, APOE, and other key gene variants relevant to your health concerns. Testing can be done via blood or saliva — simple and convenient.
01. Comprehensive Genomic Testing
02. Detailed Results Interpretation
Raw genetic data is complex. We translate your results into plain language and contextualise them within your full health picture — symptoms, lifestyle, environment, and health history all matter.
03. Targeted Nutritional & Lifestyle Support
Based on your results, we design a tailored plan including the right forms of key nutrients (e.g. methylfolate vs folic acid), dietary adjustments, lifestyle strategies, and targeted supplementation to support your methylation pathways.
04. Ongoing Monitoring & Adjustment
Genomics-informed care evolves. We monitor your response, adjust your protocol, and track key markers such as homocysteine and B12 to ensure your plan is working for you.
"Understanding your genetics is not about predicting disease — it's about empowering you with knowledge to make better choices for your long-term health and vitality."
Get Started
Ready to Understand Your Genes?
Book a Genomics Consultation and discover what your DNA can tell you about your health — and what to do about it.